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Obesity has long been considered an important cardiovascular risk factor perhaps dating from Hippocrates astute observation in 400 BC that sudden death was more common in those who are naturally fat than in the lean (Chadwick and Mann, 1950). Obesity is often associated in the metabolic syndrome with cardiovascular and metabolic abnormalities that predispose to hypertension and coronary-heart disease (CHD), and there is also evidence that obesity leads to other cardiovascular disorders, including congestive heart failure and cardiac arrhythmias (Poirier et al., 2006; NIH, 1998; Sowers, 2003; Baik, Ascherio and Rimm, 2000; Widlansky et al., 2004; Ajani, Lotufo and Gaziano, 2004) (see Table 12.1). The epidemiological evidence for these associations is reviewed in detail in 9. The relationships between obesity and cardiovascular diseases are complex. The distribution of adiposity in the body seems to be more important than total fat mass, and visceral adiposity is a particularly powerful predictor of cardiovascular disease. Evidence is also emerging that adipose tissue adjacent to the heart and arteries may in uence various cardiovascular functions and outcomes, while triglyceride deposited within the myocardium itself may adversely affect cardiac morphology and perhaps contribute to cardiac failure. The role of obesity per se is dif cult to de ne, because it is often associated with comorbidities (insulin resistance, hypertension and dyslipidaemia) that themselves predispose to cardiovascular disease. Some studies suggest that uncomplicated obesity in the absence of these comorbidities does not necessarily damage the cardiovascular system. This chapter describes the cardiovascular disorders associated with obesity, together with their likely aetiology and clinical signi cance, and discusses recent ndings that cast new light on the relationships between adiposity and the cardiovascular system.

p 0 n 1 Rn r ;

Here s what this code outputs:

16.1.6. Shadow Moire A simple method of moire interferometry for contouring objects uses a single grating placed in front of the object as shown in Figure 16.14. The grating in front of the object produces a shadow on the object which is viewed from a different direction through the grating. A low frequency beat or moire pattern is seen. This pattern is due to the interference between the grating shadows on the object and the grating as viewed. Assuming that the illumination is collimated and that the object is viewed at in nity or through a telecentric optical system, the height z between the grating and

These conditions preclude most data ever being directly transferred from the data warehouse to the operational environment. It is easy to see why there is a minimal amount of backward flow of data in the case of direct access.

In contrast, with Charm++, A invokes B on each (virtual) processor, which computes, sends initial messages, and returns to A. A then starts off module C in a similar manner. Now B and C interleave their execution based on availibility of data (messages) they are waiting for. This automatically overlaps idle time in one module with computation in the other, as shown in the gure. One can attempt to achieve such overlap in MPI, but at the cost of breaking the modularity between A, B, and C. The code in B does not have to know about that in A or C, and vice versa.

6.2: Look at the acceleration equation (3.18). 7.1: Respectively, they evolve as l/a4 , l/a 3 , constant, and l/a 2 . Radiation will dominate at early times, and the cosmological constant at late times.

information can be useful as a rst step in revealing the disulphide distribution pattern within a protein. 5.3.3 Chemical Crosslinking of Proteins Quaternary Structure Quaternary structure describes the arrangement of individual polypeptide chains in oligomeric proteins (i.e. proteins consisting of more than one polypeptide). We have already seen that secreted proteins such as immunoglobulins often consist of several polypeptide chains or subunits linked

7. To add a third image, click the Click icon to select the onclick image placeholder. 8. To activate the button s third stage, click the checkbox to the left of the file reference. 9. Point and Shoot, or otherwise link to the image you wish to display while the user clicks the mouse. 10. (Optional) If you want your button to connect to another page or location when clicked, check the URL checkbox, and then link to the location and set up the link, as shown in Figure 12-17. (As with any link, if you want the URL s path to be absolute, click the Absolute Link button. To have the destination page open in its own new browser window, choose _blank from the Target pop-up menu. If using frames, select the target frame as the target.